Constitute the appropriate number of vials as needed for the dose. Meropenem (Merrem) is an injectable carbapenem and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms Has activity versus a wide array of organisms, including multi-drug resistant Acinetobacter baumannii, Pseudomonas aeruginosa and … https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvbWVycmVtLWl2LW1lcm9wZW5lbS0zNDI1NjU=, View explanations for tiers and Gynecological infections such as endometritis. Meropenem 1 g IV q8H should be used for all severe urinary infections if the organism is susceptible. Infants <32 weeks GA and PNA <2 weeks: 20 mg/kg IV q12hr, Infants <32 weeks GA and PNA ≥2 weeks: 20 mg/kg IV q8hr, Infants ≥32 weeks GA and PNA <2 weeks: 20 mg/kg IV q8hr, Infants ≥32 weeks GA and PNA ≥2 weeks: 30 mg/kg IV q8hr, No fetal toxicity or malformations were observed in pregnant rats and Cynomolgus monkeys administered intravenous meropenem during organogenesis at doses up to 2.4 and 2.3 times the maximum recommended human dose (MRHD) based on body surface area comparison, respectively; in rats administered intravenous meropenem in late pregnancy and during lactation period, there were no adverse effects on offspring at doses equivalent to approximately 3.2 times the MRHD based on body surface area comparison. The recipient will receive more details and instructions to access this offer. Most Following a single dose of VABOMERE, pharmacokinetic studies with meropenem and vaborbactam in subjects with renal impairment have shown that meropenem AUC 0-inf ratios to subjects with normal renal function are 1.28, 2.07, and 4.63 for subjects with mild (eGFR of 60 to 89 mL/min/1.73m 2), moderate (eGFR of 30 to 59 mL/min/1.73m 2), and severe (eGFR <30 mL/min/1.73m 2) renal … 237122-overview Share cases and questions with Physicians on Medscape consult. -Diluted solution: May store at room temperature or refrigerated at 2C to 8C (36F to 46F); IV infusion must be completed within 4 or 22 hours, respectively. Access your plan list on any device – mobile or desktop. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Pneumonia, peritonitis, neutropenia, septicemia: 20 mg/kg/dose every 8 hours. prescription products. This study aimed to evaluate the effects of an empirical therapy of high-dose versus standard-dose meropenem in sepsis and septic shock patients. Use half normal dose every 24 hours if eGFR less than 10 mL/minute/1.73 m 2. Hemodialysis: Dose (adjusted for eGFR) should be administered after a hemodialysis session. This website also contains material copyrighted by 3rd parties. The easiest way to dilute meropenem is to do 2 vials at a time. Non species related breakpoints are based on the following dosages: EUCAST breakpoints apply to meropenem 1000 mg x 3 daily administered intravenously over 30 minutes as the lowest dose. Adult: In cases of severe pneumonia, complicated UTI, complicated intra-abdominal infections, complicated skin and skin structure infections, gynaecological infections: 0.5-1 g 8 hourly via infusion over approx 15-30 minutes or via bolus inj over approx 3-5 minutes. Please confirm that you would like to log out of Medscape. Safety and efficacy have not been established in patients younger than 18 years. The above information is provided for general Use: For the treatment of patients with complicated urinary tract infections (including pyelonephritis) due to susceptible Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae species complex. This drug is available at a higher level co-pay. Last updated on Nov 20, 2020. We performed a prospective randomized open-label … commonly, these are "non-preferred" brand drugs or specialty restrictions. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. • Broncho-pulmonary infections in cystic fibrosis • Complicated urinary tract … Use half normal dose every 12 hours if eGFR 10–25 mL/minute/1.73 m 2. Measuring plasma drug concentrations may guide clinicians to adjust dosing and achieve therapeutics levels avoiding toxicity and resistance emergence [ 8 ]. CONTRAINDICATIONS: Available for Android and iOS devices. Max: 1 gm/dose. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Controlled studies in pregnant women show no evidence of fetal risk. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. provider for the most current information. What Is the Risk of Catching the Coronavirus on a Plane? Reconstitution/preparation techniques: Urinary tract infections. Max: 500 mg/dose. Select one or more newsletters to continue. Meropenem Dosing Substitution • For all adults and children > 50kg (normal renal function*): ... urinary tract infection. Monitoring: -Culture and susceptibility information should be considered when selecting/modifying antibacterial therapy or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Four hundred forty-six patients (397 pediatric patients 3 months to less than 17 years of age) were enrolled in 4 separate clinical trials and randomized to treatment with meropenem (n=225) at a dose of 40 mg/kg every 8 hours or a comparator drug, i.e., cefotaxime (n=187) or ceftriaxone (n=34), at the approved dosing regimens. Other polymicrobial infections. Use normal dose every 12 hours if eGFR 26–50 mL/minute/1.73 m 2. -Only compatible with 0.9% Sodium Chloride Injection, USP -Consult physician at once if watery and bloody stools (with or without stomach cramps and fever) develop. Usual Adult Dose for Urinary Tract Infection. Meropenem Merrem ® - Renal dosing. -Serum creatinine levels and eGFR should be monitored at least daily in patients with changing renal function; the dose of this drug should be adjusted accordingly. A: Generally acceptable. meropenem, or cefepime (unless the reaction was to ceftazidime). Consult WARNINGS section for dosing related precautions. Mouthwash Might Mitigate COVID-19 Spread. -Renal: Renal function in elderly patients; serum creatinine levels and eGFR in patients with changing renal function (at least daily) Nitrofurantoin or fosfomycin may also be used for Duration of therapy: Up to 14 days Individual plans may vary By continuing to browse this site you are agreeing to our use of cookies. Peritoneal dialysis: Data not available. Meningitis and life threatening infections: 40 mg/kg IV every 8 hours. Skin and skin structure infections. IV compatibility: commonly, these are generic drugs. Adding plans allows you to compare formulary status to other drugs in the same class. Double the dose in meningitis and severe infection. Contact the applicable plan 966919-overview By clicking send, you acknowledge that you have permission to email the recipient with this information. Meropenem/vaborbactam, sold under the trade name Vabomere among others, is a fixed dose combination drug for the treatment of complicated urinary tract infections.It contains the β-lactam antibiotic meropenem and the β-lactamase inhibitor vaborbactam.In August 2017, the U.S. Food and Drug Administration (FDA) approved it to treat complicated urinary tract infections and pyelonephritis. This drug is available at a higher level co-pay. Should you take probiotics with antibiotics. Approximately 70% of the administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable. -Powder (prior to constitution): Store vials at 20C to 25C (68F to 77F); excursions permitted to 15C to 30C (59F to 86F). -Administer all doses by IV infusion over 3 hours. -Must complete IV infusion of the diluted solution within 4 hours if stored at room temperature or 22 hours if stored refrigerated. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. -Avoid missing doses and complete the entire course of therapy. Most Manage and view all your plans together – even plans in different states. Includes dosages for Skin and Structure Infection, Intraabdominal Infection, Nosocomial Pneumonia and more; plus renal, liver and dialysis adjustments. Antibiotics & Drinking Alcohol - Is it Safe? Diseases & Conditions, 2010 Estimated GFR 15 to 29 mL/min/1.73 m2: 2 g IV every 12 hours The clinical and bacteriological efficacies of meropenem in the treatment of 12 patients with urinary tract infection were studied. This drug is available at the lowest co-pay. -Estimated GFR (eGFR) based on the Modification of Diet in Renal Disease equation. dose is 10, 20 or 40 mg/kg every 8 hours (maximum dose is 2 g every 8 hours), depending on the type of infection (complicated skin and skin structure, intra-abdominal or meningitis). -Final infusion concentration (after dilution): 4 to 16 mg/mL; the manufacturer product information should be consulted. Empiric treatment for presumed infections in adult patients with febrile neutropenia. Patient advice: Ciprofloxacin or TMP/SMX can be used as alternatives to ertapenem for uncomplicated UTI if the organism is susceptible. The owner is comfortable giving SQ injections at home. Intra-abdominal infections. Indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, and Peptostreptococcus species, 500 mg IV q8hr; not to exceed 2 g IV q8hr, Indicated as a single agent therapy for the treatment of complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species, 500 mg IV q8hr for ≤5 days in combination with fluoroquinolone, Indicated as a single agent therapy for the treatment of bacterial meningitis caused by Streptococcus pneumoniae (penicillin susceptible isolates), Haemophilus influenzae, and Neisseria meningitidis, ≥3 months: 40 mg/kg IV q8hr; not to exceed 2 g IV q8hr, ≥3 months: 20 mg/kg IV q8hr; not to exceed 1 g q8hr, ≥3 months: 10 mg/kg IV q8hr; not to exceed 500 mg IV q8hr, Rash (2-3%; includes diaper-area moniliasis in pediatric patients), Oral moniliasis (≤2% in pediatric patients), Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme and acute generalized exanthematous pustulosis, Hypersensitivity to IV components, beta-lactams, or other drugs in this class, Hypersensitivity reactions have been reported, including fatalities; these reactions are more likely to occur in individuals with history of sensitivity to multiple allergens, Seizures have been reported, most commonly in patients with CNS disorders (eg, brain lesions, history of seizures) or with bacterial meningitis or compromised renal function, Seizures, headaches, or paresthesias may occur, potentially interfering with mental alertness or causing motor impairment, Clostridium difficile-associated diarrhea has been reported, To avoid development of drug resistance, drug should be used only in proven or strongly suspected bacterial infections or a prophylactic indication, Prolonged use may result in overgrowth of nonsusceptible organisms, Thrombocytopenia has been reported in patients with renal impairment, Co-administration of meropenem IV with valproic acid or divalproex sodium reduces serum concentrations of valproic acid potentially increasing risk of breakthrough seizures, Severe cutaneous adverse reactions (SCAR) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), erythema multiforme (EM) and acute generalized exanthematous pustulosis (AGEP) reported; if signs and symptoms suggestive of these reactions appear, therapy should be withdrawn immediately and an alternative treatment considered, There are insufficient human data to establish whether there is a drug-associated risk of major birth defects or miscarriages with meropenem in pregnant women, Drug has been reported to be excreted in human milk; no information is available on effects of drug on breast-fed child or on milk production; the developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for therapy and any potential adverse effects on breast-fed child from therapy or from the underlying maternal condition. Examples: 1) Prescriber orders meropenem 1g q8hr in a patient with meningitis. Meropenem Updated September 2016 $48.50 for 500mg $63.50 for 1g Example A 30kg dog has a resistant urinary tract infection that is sensitive to meropenem. complex. {{configCtrl2.info.metaDescription}} This site uses cookies. The dog is stable and ready to be discharged from the hospital. 2 g x 3 daily was taken into consideration for severe infections and in setting the I/R breakpoint. View the formulary and any restrictions for each plan. Comments: Storage requirements: Medically reviewed by Drugs.com. Most Burgos RM(1), Biagi MJ(1), Rodvold KA(1)(2), Danziger LH(1)(2). Diseases & Conditions, encoded search term (meropenem (Merrem IV)) and meropenem (Merrem IV), Opportunities to Improve Antibiotic Appropriateness in U.S. ICUs, FDA Panel Recommends Cefiderocol for Complicated UTI, Pleural Effusion as an Atypical Presentation of Kawasaki Disease, Rinse and Repeat? commonly, these are "preferred" (on formulary) brand drugs. -Do not operate machinery or motorized vehicles until it is reasonably well established that this drug is well tolerated. Applies to the following strengths: 1 g-1 g, 4 g IV every 8 hours Administration advice: In 8 patients the drug was administered intravenously in a dose of 1 g every 8 hours and in 4 patients with the creatinine clearance below 50 ml/min it was administered in a dose of 1 g every 12 hours (the treatment course of 7 to 10 days). General: We comply with the HONcode standard for trustworthy health information -, Drug class: carbapenems/beta-lactamase inhibitors. -Total duration of therapy is for up to 14 days. Your list will be saved and can be edited at any time. Withdraw 20 mL of 0.9% Sodium Chloride Injection from an infusion bag and constitute each vial. These are the only indications for which this dose is appropriate. In this randomized, phase 3, non-inferiority trial, adults aged 18 years or older with hospital-acquired, ventilator- or, healthcare-associated Gram-negative pneumonia were enrolled. Klebsiella pneumoniae has been frequently found to produce extended-spectrum β-lactamases (ESBLs).1 Infections caused by ESBL-producing pathogens are problematic because when co-resistance to other antimicrobial class is present, limited antibiotic options are available. -The constituted solution must be diluted further (immediately) in a 0.9% Sodium Chloride Injection, USP infusion bag prior to IV infusion. merrem-iv-meropenem-342565 If continued treatment with MEROPENEM RANBAXY for Injection is necessary, the unit dose (based on the type and severity of infection) is recommended at the completion of the haemodialysis procedure to … commonly, these are "non-preferred" brand drugs. -Known hypersensitivity to either active component, any of the ingredients, or other drugs in the same class The FDA has approved a fixed-dose combination of meropenem, a carbapenem antibiotic, and vaborbactam, a new beta-lactamase inhibitor (Vabomere – Melinta), for IV treatment of adults with complicated urinary tract infections (UTIs) that are proven or strongly suspected to be caused by Escherichia coli, Klebsiella pneumoniae, or Enterobacter cloacae spp. Pneumonias and nosocomial pneumonia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Meropenem is given intravenously by infusion or slow injection every 8 hours. imipenem MIC of 4mg/L, the meropenem dose should be adjusted to 2 g q8hr. Estimated GFR less than 15 mL/min/1.73 m2: 1 g IV every 12 hours -Compatibility with other drugs not established. Meropenem is a safe and effective broad-spectrum antibiotic, commonly used in the intensive care unit, and it is a good therapeutic tool for management of severe urinary tract sepsis .

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